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KMID : 0369819830130010010
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Jorunal of Korean Pharmaceutical Sciences
1983 Volume.13 No. 1 p.10 ~ p.22
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Pharmaceutical Studies on the Inclusion Complexes of Non - Steroidal Antiinflammatory Drugs with β- Cyclodextrin (Ⅰ)
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한건/Han K
이민화/김신근/Lee MH/Kim SK
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Abstract
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The interactions of α-cyclodextrin(α-CyD) and β-cyclodextrin(β-CyD) with several non-steroidal antiinflammatory drugs were studied on the effects of α- and β-CyD on the solubility of the drugs in aqueous medium. Indoprofen, niflumic acid, alclofenac, and naproxen were chosen as representatives of antiinflammatory drugs. The solubility of all drugs studied increased with the addition of β-CyD, while not with glucose or α-CyD. The increase of the solubility- with β-CyD was considered due mainly to the formation of inclusion complexes between β-CyD and drugs. From the solubility data, the apparent stability constants K of the complex could be calculated. Ultraviolet absorption and circular dichroism confirmed the inclusion of indoprofen, niflumic acid and naproxen with β-CyD in the molar ratio of 1 : 1. Inclusion complexes in solid powder form were obtained by the freeze-drying method and the inclusion formation was confirmed again by infrared, diffential thermal analysis, and X-ray diffraction measurements.
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